Recent advances in central cardiovascular control: sex, ROS, gas and inflammation [version 1; referees: 2 approved]
نویسندگان
چکیده
The central nervous system (CNS) in concert with the heart and vasculature is essential to maintaining cardiovascular (CV) homeostasis. In recent years, our understanding of CNS control of blood pressure regulation (and dysregulation leading to hypertension) has evolved substantially to include (i) the actions of signaling molecules that are not classically viewed as CV signaling molecules, some of which exert effects at CNS targets in a non-traditional manner, and (ii) CNS locations not traditionally viewed as central autonomic cardiovascular centers. This review summarizes recent work implicating immune signals and reproductive hormones, as well as gasotransmitters and reactive oxygen species in the pathogenesis of hypertension at traditional CV control centers. Additionally, recent work implicating non-conventional CNS structures in CV regulation is discussed. Alastair V. Ferguson ( ) Corresponding author: [email protected] Smith PM and Ferguson AV. How to cite this article: Recent advances in central cardiovascular control: sex, ROS, gas and inflammation 2016, (F1000 Faculty Rev):420 (doi: ) [version 1; referees: 2 approved] F1000Research 5 10.12688/f1000research.7987.1 © 2016 Smith PM and Ferguson AV. This is an open access article distributed under the terms of the Copyright: Creative Commons Attribution , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Licence This work was supported by a grant from the Canadian Institutes for Health Research. Grant information: Competing interests: The authors declare that they have no competing interests. 31 Mar 2016, (F1000 Faculty Rev):420 (doi: ) First published: 5 10.12688/f1000research.7987.1 Referee Status:
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Recent advances in central cardiovascular control: sex, ROS, gas and inflammation
The central nervous system (CNS) in concert with the heart and vasculature is essential to maintaining cardiovascular (CV) homeostasis. In recent years, our understanding of CNS control of blood pressure regulation (and dysregulation leading to hypertension) has evolved substantially to include (i) the actions of signaling molecules that are not classically viewed as CV signaling molecules, som...
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